There is no doubt that menopause is an extremely overwhelming phase in any woman’s life. She undergoes various changes; physically, mentally and emotionally. As the hormone levels drop, health issues start to rise. Her bones get affected too. Post-menopausal women are at high risk of developing osteoporosis or fragile bone disease. As per the latest bone health statistics, globally, osteoporosis is responsible for over 8.9 million fractures annually. It means every 3 seconds an osteoporotic fracture is being reported. Also, studies and surveys have concluded that the bone condition affects 200 million women across the globe. In fact, one in three women above the age 50 is at the risk of experiencing fracture due to osteoporosis.
Let’s face the fact that osteoporosis is not curable. With the right set of medicines, lifestyle changes such as consuming foods rich in calcium and vitamin D, and regular exercise routine can help you to reverse the bone disease; also, can help you to stop its effects on the bone density. However, these changes alone aren’t sufficient. That’s when osteoporosis medicines step in.
This article will help you understand about one of the widely used medicines for the treatment of osteoporosis – Raloxifene. You will learn how the medicine works, which side effects it produces, and its long-term effects, and much more. Likewise, we are going to learn about osteoporosis. Let’s dive right in!
What is osteoporosis?
Osteoporosis is a bone disease which is indicated by symptoms such as reduced bone density, worsening of bone tissue, and commotion of bone microarchitecture. These lead to diminished bone strength which further increases the risk of bone fractures.
Osteoporosis is commonly found in post-menopausal women, Caucasians, and elderly people. As mentioned earlier, it is one of the major reasons for increased risk for bone fractures. Osteoporosis is commonly caused in both the genders and all races, and its risk increases with age. The bone disease progresses silently until you experience a fracture, which lead to secondary problems, and in some rare cases, death too.
What causes osteoporosis?
Calcium and other minerals’ concentration within the bones partially determines their strength and density. Your body constantly absorbs old bone cells and give birth to new bone cells. This process is faster in young people, and also you make more bones than you lose. In post 30s, the process gets slower which means you lose more bone cells as compared to the new bone cells formation ratio.
The amount of calcium and other minerals in your bones during your 30s imposes your risk of developing osteoporosis later in life. The bone less significantly increases in women especially during the menopause. Though there are multiple reasons behind bone loss, genetic factors can be held responsible for almost 60 to 80% of bone loss.
Raloxifene for osteoporosis
A selective estrogen receptor modulator, Raloxifene Hawaii possesses an estrogen-agonistic effect on the bone receptors. This activity frameworks the usages, mechanism of action, and contraindications of Raloxifene as a valued element in the treatment of osteoporosis.
Doctors advised to buy Raloxifene for the treatment of 1) osteoporosis, and 2) the reduction of risk of invasive breast cancer in women.
For osteoporosis, Raloxifene increases the bone mineral density by reducing bone resorption. Therefore, it is widely indicated for treating and preventing osteoporosis in post-menopausal women.
Raloxifene Kentucky is also used in the risk reduction of invasive breast cancer in post-menopausal women.
Studies have estimated that Raloxifene can also be used as an ancillary treatment for schizophrenia in post-menopausal women. It shows better results in treating mild symptoms of schizophrenia.
How does Raloxifene work?
The mechanism of action of Raloxifene involves binding to the estrogen receptors. This further results in estrogen-agonistic effect via estrogenic pathways. Raloxifene inhibits the bone resorption thus improving bone mineral density and boosting bone strength.
Raloxifene is not a cure for osteoporosis. It does reverse the effects of osteoporosis either. However, it does help in restoring the bone mineral density which leads to stronger bones.
Reference Links
https://www.tandfonline.com/doi/full/10.1080/13697137.2021.1965408
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335887/
https://www.webmd.com/osteoporosis/what-to-know-about-osteoporosis-medshttps://www.stlukes-stl.com/health- content/medicine/33/000120.htm#:~:text=Treatment%20Options&text=While%20calcium%20by%20itself%20does,can%20also%20enhance%20bone%20strength